Inhibition of Effects of Acetylcholine at Neuromuscular Junction by Omeprazole

Aim: To assess the effect of Omeprazole at neuromuscular junction with and without Pancuronium. Study design: Experimental randomized control study. Place duration study: Department Pharmacology, Islamic International Medical College, Rawalpindi from October 2018 to September 2019 Methods: In this experimental study both a student’s oscillograph cumulative dosage response curve were used record frog's rectus abdominis muscle contracting in acetylcholine (control group). Three groups' responses omeprazole, before after adding pancuronium, noted. The student's t test was conduct statistical analysis variance (ANOVA) between groups, p-value 0.05 or below regarded as statistically significant. Results: By blocking neurotransmitter acetylcholine, omeprazole dose 3.5 M concentration altered right mean deviation 23.7% (SEM ± 20.5). presence 1 g likewise caused shift 37 percent ±10.5). change demonstrated agonistic impact on NMJ blockers like pancuronium significant (p < 0.05). Conclusion: 3.5µM strength inhibits effects Acetylcholine junction, however, it potentiates Pancuronium same strength. Keywords: Acetylcholine, Neuromuscular Junction, Pancuronium, Omeprazole.